The leading cause of death in HIV-infected individuals.
Weakened immune system
Limits sensitivity of diagnosis of TB
Support vector machine to find 251-gene signature
Genes involved in Immunological, Infectious and Inflammatory Disease
Limits sensitivity of diagnosis of TB
Our aim:
Explore genes with a significant expression enriched in HIV with TB co-infection
Compare with the 251-gene signature found with the SVM model
Data handling:
Select variables
Mutate variables
Handle key-variable
Handle replications
Normalization Log2

First PC explains 15% of the variance
31 PCs needed to explain 90% of variance
Forest plot
Volcano plot